Many fans braved the wind and rain to greet Streep and fellow stars of the film Jim Broadbent, Olivia Colman, Richard E. Grant and Anthony Head on the red carpet.
Mamma Mia's Phyllida Lloyd has directed the moving story written by The Hour's Abi Morgan, which sees the former leader, lonely and senile, looking back on her life and imagining her late husband Denis Thatcher, played by Broadbent, is still with her.
Streep has been tipped for an Oscar nomination for the role, which could lead to her third win.
She said: "It would be great, because the secret of the nomination is that it comes from the actors and actors are the ones who know what you go through. So it would be amazing."
The Thatcher family have snubbed an invitation to see the film.
Director Lloyd said: "We invited them to see the film when we'd just completed it and they didn't come to see it at that time, which I quite understand. The probably want to watch it in the privacy of their own home. I think that's how I would have reacted if it had been a film about my family."
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